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Human iPSC-Based Modeling Identifies Epigenetic Regulation at the KCNQ1 Locus During Early Islet Development That Contributes to Lower β-Cell Mass.

Diabetes - 1 Jun 2026

Nair Anup K, Traurig Michael, Muller Yunhua L, Anup Divya, Sutherland Jeffrey R, Grellinger Emma, Henry Nizhoni, Weidrich Kim, Cheranda Koushik Ponnanna, Bogardus Clifton, Baier Leslie J

Abstract excerpt

The strongest type 2 diabetes signal in Indigenous Americans from Arizona is in intron 15 of KCNQ1. We previously identified a functional region in this intron that contained four type 2 diabetes-associated single nucleotide polymorphisms (SNPs) (rs2299620, rs2237896, rs2237897, and rs74046911) and demonstrated functionality of this fragment using Indigenous American induced pluripotent stem cell (iPSC)-derived...

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Share to Diabetes Mellitus, Type 2
Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Induced Pluripotent Stem Cells
Share to Insulin-Secreting Cells
Share to Islets of Langerhans
Share to KCNQ1 Potassium Channel
Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41945357
DOI: 10.2337/db25-0721
PMCID: PMC13191422

Genes

KCNQ1
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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