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ALTercations at telomeres: stress, recombination and extrachromosomal affairs

28 Sept 2023

Abstract excerpt

Approximately 15% of human cancers depend on the alternative lengthening of telomeres (ALT) pathway to maintain telomeres and proliferate. Telomeres that are elongated using ALT display unique features raising the exciting prospect of tailored cancer therapies. ALT-mediated telomere elongation shares several features with recombination-based DNA repair. Strikingly, cells that use the ALT pathway display abnormal...

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PMID: 37767563
DOI: 10.1042/bst20230265

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