Article

Telomere-loop dynamics in chromosome end protection

2018-03-09

Abstract excerpt

<h4>SUMMARY</h4> We used super-resolution microscopy to investigate the role of macromolecular telomere structure in chromosome end protection. In murine and human cells with reduced TRF2, we find that ATM-activation at chromosome ends occurs with a structural change from t-loops to linearized chromosome ends through t-loop unfolding. Comparably, we find Aurora B kinase regulates telomere linearity concurrent wit...

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Literature Corpus work: 10f7bbdd-068f-517f-8e75-cc0f1c0dfbbf
DOI: 10.1101/279877

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