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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

29 Mar 2023

Abstract excerpt

Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% - 10% of human cancers rely on a recombination-based mechanism termed alternative lengthening of telomeres (ALT) to sustain their replicative immortality, yet there are currently no targeted therapies. Through CRISPR/Cas9-based genetic screens in an ALT-immortalized isogenic cellular model, here we identify histone lysine...

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PMID: 36991019
DOI: 10.1038/s41467-023-37480-2

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