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Article

Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.

Trends in cancer - 1 Mar 2020

Hoang Song My, O'Sullivan Roderick J

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a mechanism of telomere maintenance that is observed in many of the most recalcitrant cancer subtypes. Telomeres in ALT cancer cells exhibit a distinctive nucleoprotein architecture shaped by the mismanagement of chromatin that fosters cycles of DNA damage and replicative stress that activate homology-directed repair (HDR). Mutations in specific chromatin-remodeling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32101727
DOI: 10.1016/j.trecan.2019.12.009
PMCID: PMC7199893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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