Article

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

2023-02-11

Abstract excerpt

Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% - 10% of human cancers rely on a recombination-based mechanism termed alternative lengthening of telomeres (ALT) to sustain their replicative immortality, yet there are currently no targeted therapies. Through CRISPR/Cas9-based genetic screens in an ALT-immortalized isogenic cellular model, here we identify histone lysine d...

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Literature Corpus work: 47503c53-94e9-5044-852c-9a91641668c6
DOI: 10.1101/2023.02.10.528023

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