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Article

Impact of azithromycin treatment on macrophage gene expression in subjects with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2014

Cory Theodore J, Birket Susan E, Murphy Brian S, Hayes Don, Anstead Michael I, Kanga Jamshed F, Kuhn Robert J, Bush Heather M, Feola David J

Abstract excerpt

BACKGROUND: Azithromycin treatment improves clinical parameters in patients with CF, and alters macrophage activation from a pro-inflammatory (M1) phenotype to a pro-fibrotic, alternatively activated (M2) phenotype. The transcriptional profile of cells from patients receiving azithromycin is unknown. METHODS: Gene expression in association with macrophage polarization, inflammation, and tissue remodeling was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24018177
DOI: 10.1016/j.jcf.2013.08.007
PMCID: PMC4376357

Genes

NOS2
CCL18
MMP9
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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