Article
Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis.
American journal of respiratory cell and molecular biology - 1 Nov 2009
Meyer Magali, Huaux François, Gavilanes Ximena, van den Brûle Sybille, Lebecque Patrick, Lo Re Sandra, Lison Dominique, Scholte Bob, Wallemacq Pierre, Leal Teresinha
Abstract excerpt
Macrophages phagocyte pathogenic microorganisms and orchestrate immune responses by producing a variety of inflammatory mediators. The cystic fibrosis (CF) transmembrane conductance regulator chloride channel has been reported to be of pivotal importance for macrophage functions. The exact phenotype and role of macrophages in CF is still unknown. Alveolar and peritoneal macrophages were monitored in CF mice...
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