Article

Astrocytic HDAC7 Activates IKK/NF-κB Signaling to Regulate Neuroinflammation and Anxiety-like Disorders

2022-03-24

Abstract excerpt

<title>Abstract</title> <p>Class IIa histone deacetylase s (HDAC) have been shown to drive innate immune cell-mediated inflammation in the peripheral system, but their roles in cerebral inflammatory responses remain largely unknown. Here, we elucidate that HDAC7 is selectively elevated in lipopolysaccharide (LPS)-challenged astrocytes both in vivo and in vitro. We identify that HDAC7 binds to the inhibitory kappa...

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Literature Corpus work: 90038d71-f614-58c0-940b-d3fd555ec5ec
DOI: 10.21203/rs.3.rs-1462010/v1

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Astrocytic HDAC7 Activates IKK/NF-κB Signaling to Regulate Neuroinflammation and Anxiety-like DisordersDOI 10.21203/rs.3.rs-1462010/v1Read

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