Metabolic Control of Glycosylation Forms for Establishing Glycan-Dependent Protein Interaction Networks

Abstract excerpt

<h4>SUMMARY</h4> Protein-protein interactions (PPIs) provide essential insights into the complex molecular mechanisms and signaling pathways within cells that regulate development and disease-related phenotypes. However, for membrane proteins, the impact of various forms of glycosylation has often been overlooked in PPI studies. In this study, we introduce a novel approach, glycan-dependent affinity purification...

Topics

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• Diabetes Mellitus
• Disease Susceptibility
• Environment
• Glycosylation and Glycoproteins Research
• Mass Spectrometry
• Monoclonal and Polyclonal Antibodies Research
• Protein Interaction Mapping
• Protein Interaction Maps

Identifiers and source

Literature Corpus work

98e9e15a-84b6-51ab-93ec-61d6ff71586f

DOI

10.1101/2024.10.30.621210