Article

IFNγ-dependent remodelling of the myeloid landscape underlies control of IFNγ-insensitive tumours

2024-03-28

Abstract excerpt

Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, as some cancers lacking IFNγ-signalling demonstrate resistance to checkpoint immunotherapy. However, recent studies demonstrated that IFNγ-resistant tumours are well-controlled and sensitized for immunotherapy. The underlying mechanism leading to enhanced immune responses in those patients is unknown. Using IFNγ-insensitive melanoma...

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Literature Corpus work: e1107316-02ee-5d44-b33c-2b2e627954c2
DOI: 10.1101/2024.03.25.586537

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