CD4+ T cell-induced inflammatory killing controls immune evasive tumours

Abstract excerpt

<title>Abstract</title> <p>Current clinically applied cancer immunotherapies largely focus on the ability of CD8+ cytolytic T-cells to directly recognise and kill tumour cells1–3. These strategies are limited by the emergence of MHC-I-deficient or IFN-unresponsive tumour cells and the development of an immunosuppressive tumour microenvironment4–6. CD4+ effector T-cells can contribute to tumour immune defence inde...

Topics

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• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• CD8-Positive T-Lymphocytes
• Coculture Techniques
• Cytotoxicity, Immunologic
• gp100 Melanoma Antigen
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses

Identifiers and source

Literature Corpus work

3a919d3a-a3cc-5e04-9db7-4032dd198405

DOI

10.21203/rs.3.rs-1764653/v1