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Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma

31 Dec 2024

Abstract excerpt

BACKGROUND: Melanoma cells frequently dedifferentiate in response to inflammation which can increase responses to certain cytokines. Interferon-γ (IFNγ) is an integral part of the anti-tumor immune response and can directly induce both differentiational changes and expression of immunosuppressive proteins in melanoma cells. How the differentiation status of melanoma cells affects IFNγ responses remains unclear....

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PMID: 39736644
DOI: 10.1186/s12964-024-01963-6

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