Article

The molecular mechanism of uptake and cell-to-cell transmission of arginine-containing dipeptide repeat proteins

2025-11-28

Abstract excerpt

Micro-satellite repeat expansion of the 5’ GGGGCC 3’ sequence in the C9orf72 gene is the most common monogenic form of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) translated from the mutant allele can be detected in postmortem brains of afflicted individuals. The arginine containing peptides, poly-PR and poly-GR, are particularly noxious to cells. Both h...

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Literature Corpus work: 5ccb86ca-d257-58c0-bc67-9b24f89c4c3a
DOI: 10.1101/2025.11.25.690484

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