Impaired nucleocytoplasmic transport in SOD1-mediated ALS.

doi:10.1186/s13024-026-00930-8

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Article

Impaired nucleocytoplasmic transport in SOD1-mediated ALS.

Molecular neurodegeneration - 14 Feb 2026

Argueti-Ostrovsky Shirel, Lim Su Min, Arogundade Olubankole A, Diaz-Garcia Sandra, Yunisova Gulshan, Meng Alex, Hermann Anita, Ong Kailee, Eremenko Ekaterina, Bravo-Hernandez Mariana, Driscoll Shawn P, Lee Chao-Zong, Jiang Xin, Stavsky Alexandra, Barel Shir, Shani Tom, Kahn Joy, Pfaff Samuel L, Monsonego Alon, Marsala Martin, Ravits John, Lagier-Tourenne Clotilde, Israelson Adrian

Abstract excerpt

BACKGROUND: Impaired nucleocytoplasmic transport (NCT) has emerged as a shared pathogenic mechanism in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in the gene encoding superoxide dismutase 1 (SOD1) account for approximately 20% of familial ALS cases, the impact of mutant SOD1 accumulation on the NCT remains unclear. METHODS: Utilizing in vitro and in vivo...

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Identifiers

PMID: 41691309
DOI: 10.1186/s13024-026-00930-8
PMCID: PMC12922372

Genes

SOD1
XPO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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