Article

The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Angiotensin II-mediated Functions in Mice

2019-12-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Renin cleavage of angiotensinogen (AGT) has species specificity. Since the residues at positions 11 and 12 of AGT are different between human and mouse AGT, we determined whether these two residues in AGT affect renin cleavage and angiotensin II-mediated functions using an adeno-associated viral (AAV) approach for manipulating AGT in vivo. <h4>Approach and Results</h4> Hepat...

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Literature Corpus work: e0ff0e09-75da-5d82-a50b-eb640826bd2b
DOI: 10.1101/2019.12.18.875914

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