Article
Angiotensinogen and angiotensin-converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice.
Journal of hypertension - 1 May 2005
Alexiou Theodora, Boon Wee Ming, Denton Derek A, Nicolantonio Robert Di, Walker Lesley L, McKinley Michael J, Campbell Duncan J
Abstract excerpt
OBJECTIVE: To test the hypothesis that changes in gene expression that may accompany angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) gene polymorphism cause alteration in angiotensin and bradykinin peptide levels. DESIGN: Mice with one or two genes for AGT and ACE allow assessment of the effects of modest alteration in AGT and ACE gene expression on angiotensin and bradykinin peptide levels....
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