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Article

Functional expression of the human angiotensinogen gene in transgenic mice.

1 Dec 1994

Abstract excerpt

The renin-angiotensin system is a major determinant of arterial pressure and volume homeostasis in mammals through the actions of angiotensin II, the proteolytic digestion product of angiotensinogen. Molecular genetic studies in several human populations have revealed genetic linkage between the angiotensinogen gene and both hypertension and increased plasma angiotensinogen. Transgenic mice were generated with a...

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PMID: 7798251
DOI: 10.1016/s0021-9258(18)31662-4

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