Article
Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism.
The Journal of biological chemistry - 25 Nov 2016
Wei Hudie, Cai Haiyan, Wu Jiawei, Wei Zhenquan, Zhang Fei, Huang Xin, Ma Lina, Feng Lingling, Zhang Ruoxi, Wang Yunjie, Ragg Hermann, Zheng Ying, Zhou Aiwu
Abstract excerpt
Lamprey angiotensinogen (l-ANT) is a hormone carrier in the regulation of blood pressure, but it is also a heparin-dependent thrombin inhibitor in lamprey blood coagulation system. The detailed mechanisms on how angiotensin is carried by l-ANT and how heparin binds l-ANT and mediates thrombin inhibition are unclear. Here we have solved the crystal structure of cleaved l-ANT at 2.7 Å resolution and characterized...
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