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Article

Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2015

Wu Congqing, Xu Yinchuan, Lu Hong, Howatt Deborah A, Balakrishnan Anju, Moorleghen Jessica J, Vander Kooi Craig W, Cassis Lisa A, Wang Jian-an, Daugherty Alan

Abstract excerpt

Renin cleavage of angiotensinogen (AGT) releases angiotensin I (AngI) in the initial step of producing all angiotensin peptides. It has been suggested recently that redox regulation of a disulfide bond in AGT involving Cys18-Cys137 may be important to its renin cleavage efficiency in vivo. The purpose of this study was to test this prediction in a mouse model by comparing AngII production and AngII-dependent...

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Source

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Identifiers

PMID: 25691624
DOI: 10.1161/HYPERTENSIONAHA.115.05166
PMCID: PMC4359061

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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