Article

Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s disease

2025-01-25

Abstract excerpt

<h4>ABSTRACT</h4> While cerebrovascular dysfunction and reactive astrocytosis are extensively characterized hallmarks of Alzheimer’s disease (AD) and related dementias, the dynamic relationship between reactive astrocytes and cerebral vessels remains poorly understood. Here, we used jGCaMP8f and two photon microscopy to investigate Ca 2+ signaling in multiple astrocyte subcompartments, concurrent with changes in...

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Literature Corpus work: 2a284081-592f-5057-9f3c-8c43159d4808
DOI: 10.1101/2025.01.24.634584

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