Article

Tumor-myeloid crosstalk drives therapy resistance in localized bladder cancer

2025-09-13

Abstract excerpt

Neoadjuvant cisplatin-based chemotherapy results in pathologic complete response for only a minority of patients with muscle-invasive bladder cancer (MIBC), and mechanisms of resistance and the effects of chemotherapy on the MIBC microenvironment remain incompletely understood. Here, we defined the single-cell and spatial transcriptomes of cancer and immune cells from MIBC patients with resistance to cisplatin-bas...

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Literature Corpus work: e0cc286c-54fe-5681-b53c-145de7118645
DOI: 10.1101/2025.09.08.674862

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