Article

Single-cell trajectories in metastatic urothelial carcinoma reveal tumor–immune reprogramming and macrophage-driven resistance to PD-(L)1 blockade

2026-04-02

Abstract excerpt

Immune checkpoint inhibitors (ICI) improved outcomes in metastatic urothelial carcinoma (mUC), but primary and acquired resistance remain poorly understood. We performed single-nuclei RNA sequencing on sequential metastatic biopsies from ICI-treated mUC patients. Tumor cells showed transcriptomic heterogeneity within individual lesions, basal cells being associated with increased immune infiltration and response....

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Literature Corpus work: 63561539-bdee-5658-a9ca-1306f0b8a25e
DOI: 10.64898/2026.03.31.715549

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