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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics

30 Jan 2025

Abstract excerpt

BACKGROUND: The progression of bladder cancer (BC) from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, the heterogeneity of tumor cells and TME components remains underexplored. METHODS: We characterized the transcriptomes of single cells from 11 BC...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 39885578
DOI: 10.1186/s12967-025-06138-6

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