Article

Generation of novel diagnostic and therapeutic exosomes to detect and deplete pro-tumorigenic M2-macrophages

2019-11-20

Abstract excerpt

Given their pro-tumorigenic function and prevalence in most malignant tumors with lower survival, early detection and intervention of CD206-positive M2-macrophages may boost the clinical outcome. To determine in vivo distribution of M2-macrophages, we adopted 111 In-oxine-based radiolabeling of the targeted exosomes. When injected these radiolabeled targeted exosomes into breast tumor-bearing mice, exosomes accu...

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Literature Corpus work: e0b6adf1-ed0e-5872-b10a-a80c253f055a
DOI: 10.1101/849448

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