Article
Inhibition of furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities.
Cell death & disease - 4 Dec 2024
Ziane-Chaouche Lydia, Raffo-Romero Antonella, Hajjaji Nawale, Kobeissy Firas, Pinheiro Donna, Aboulouard Soulaimane, Cozzani Adeline, Mitra Suman, Fournier Isabelle, Cizkova Dasa, Salzet Michel, Duhamel Marie
Abstract excerpt
Chimeric antigen receptor (CAR)-T-cell therapy has revolutionized cellular immunotherapy, demonstrating remarkable efficacy in hematological cancers. However, its application in solid tumors faces significant challenges, including limited T-cell infiltration and tumor-induced immunosuppression. Given the prominent role of macrophages in the tumor microenvironment, their phenotypic plasticity and inherent...
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