Article

Combination siRNA delivery as a therapeutic strategy for ADPKD

2026-07-21

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease worldwide, characterized by progressive cyst growth and inflammation, yet effective targeted therapies remain limited. Here we show that TMEM16A and MCP-1, key mediators of cyst-lining epithelial expansion and inflammatory macrophage recruitment respectively, are consistently upregulated in cyst-lining collecting duct (C...

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Literature Corpus work: e09b0aa6-7d19-5258-a1a9-b5f2cd0db72a
DOI: 10.64898/2026.07.20.739663

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