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Article

Therapeutic microRNAs in polycystic kidney disease

8 Apr 2017

Abstract excerpt

PURPOSE OF REVIEW: microRNAs (miRNAs) are short noncoding RNAs that function as sequence-specific inhibitors of gene expression. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of end-stage kidney failure with limited treatment options. The realization that miRNA upregulation, and thus its gain-of-function, can drive the progression of ADPKD has raised the possibility that...

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PMID: 28399020
DOI: 10.1097/mnh.0000000000000333

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