Article

<i>PKD1</i> and <i>PKD2</i> mRNA cis-inhibition drives polycystic kidney disease progression

2022-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD), among the most common human genetic conditions and a frequent etiology of kidney failure, is primarily caused by heterozygous PKD1 mutations. Kidney cyst formation ensues when the PKD1 dosage falls below a critical threshold. However, no framework exists to harness the remaining allele or reverse PKD1 decline. Here, we show that mRNAs prod...

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Literature Corpus work: fa6adf39-098d-5093-8deb-5b2b9990b315
DOI: 10.1101/2022.02.23.479396

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