Article

Pirfenidone treatment attenuates fibrosis in autosomal dominant polycystic kidney disease

2025-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD) is a leading genetic cause of kidney failure, marked by progressive cyst expansion, inflammation and fibrosis. Renal fibrosis, characterized by myofibroblast activation and excessive extracellular matrix (ECM) deposition is a central driver of disease progression in ADPKD, yet targeted anti-fibrotic therapies remain limited. Here, we evaluated...

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Literature Corpus work: 53a0617b-ee98-584f-8c6f-4b571697bfcf
DOI: 10.1101/2025.08.25.672225

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