Article

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse model

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The limited treatment options available for the estimated 38% of adults worldwide affected by Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) are largely due to an incomplete understanding of the complex molecular networks underlying disease pathogenesis. To dissect the genetic architecture and proteomic regulation underlying MASLD, we generated a genetically diverse mouse cohor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0883187-c80e-5561-910b-4d2d5363d427
DOI: 10.64898/2026.07.26.740836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse modelDOI 10.64898/2026.07.26.740836Read

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.Semantic proximity Read

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.Semantic proximity Read

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.Semantic proximity Read

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic isletSemantic proximity Read

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.Semantic proximity Read

A mouse systems genetics approach reveals common and uncommon genetic modifiers of hepatic lysosomal enzyme activities and glycosphingolipidsSemantic proximity Read

System-wide quantitative proteomics of the metabolic syndrome in mice: genotypic and dietary effectsSemantic proximity Read

The genetic architecture of NAFLD among inbred strains of miceSemantic proximity Read

Defining the consequences of genetic variation on a proteome-wide scale.Semantic proximity Read

An integrated proteogenomic investigation of the human liver uncovers molecular drivers of steatotic liver diseaseSemantic proximity Read

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease.Semantic proximity Read

Regulation of protein abundance in genetically diverse mouse populationsSemantic proximity Read