Article
Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease.
Cell systems - 24 Jan 2018
Chella Krishnan Karthickeyan, Kurt Zeyneb, Barrere-Cain Rio, Sabir Simon, Das Aditi, Floyd Raquel, Vergnes Laurent, Zhao Yuqi, Che Nam, Charugundla Sarada, Qi Hannah, Zhou Zhiqiang, Meng Yonghong, Pan Calvin, Seldin Marcus M, Norheim Frode, Hui Simon, Reue Karen, Lusis Aldons J, Yang Xia
Abstract excerpt
The etiology of non-alcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, is poorly understood. To understand the causal mechanisms underlying NAFLD, we conducted a multi-omics, multi-tissue integrative study using the Hybrid Mouse Diversity Panel, consisting of ∼100 strains of mice with various degrees of NAFLD. We identified both tissue-specific biological processes and processes...
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