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Article

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

Cell systems - 27 Jun 2018

Jha Pooja, McDevitt Molly T, Gupta Rahul, Quiros Pedro M, Williams Evan G, Gariani Karim, Sleiman Maroun B, Diserens Leo, Jochem Adam, Ulbrich Arne, Coon Joshua J, Auwerx Johan, Pagliarini David J

Abstract excerpt

The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with complementary multi-omics datasets. We identified several lipid species and lipid clusters with specific phenotypic and...

Topics

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Diet, High-Fat
Lipid Metabolism
Lipids
Liver
Mice, Inbred DBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Non-alcoholic Fatty Liver Disease

Quantitative Trait Loci

Reproducibility of Results

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Identifiers

PMID: 29909277
DOI: 10.1016/j.cels.2018.05.016
PMCID: PMC6054463

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