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Article

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.

Molecular systems biology - 1 Jan 2021

Norheim Frode, Chella Krishnan Karthickeyan, Bjellaas Thomas, Vergnes Laurent, Pan Calvin, Parks Brian W, Meng Yonghong, Lang Jennifer, Ward James A, Reue Karen, Mehrabian Margarete, Gundersen Thomas E, Péterfy Miklós, Dalen Knut T, Drevon Christian A, Hui Simon T, Lusis Aldons J, Seldin Marcus M

Abstract excerpt

To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high-fat/high-sucrose diet for 8 weeks. Association mapping, correlation, structure analyses, and network modeling revealed pathways and genes underlying these interactions. In particular,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33417276
DOI: 10.15252/msb.20209684
PMCID: PMC7792507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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