Article

A mouse systems genetics approach reveals common and uncommon genetic modifiers of hepatic lysosomal enzyme activities and glycosphingolipids

2022-12-28

Abstract excerpt

<title>Abstract</title> <p>Identification of genetic modulators of lysosomal enzyme activities and glycosphingolipids (GSLs) may facilitate the development of therapeutics for diseases in which they participate, including Lysosomal Storage Disorders (LSDs). To this end, we used a systems genetics approach: we measured 11 hepatic lysosomal enzymes and many of their natural substrates (GSLs), followed by modifier g...

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Literature Corpus work: dcbe10fc-c90c-5c52-8088-b9553c69d65a
DOI: 10.21203/rs.3.rs-2362074/v1

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