Article

Regulation of protein abundance in genetically diverse mouse populations

2020-09-18

Abstract excerpt

Proteins constitute much of the structure and functional machinery of cells, forming signaling networks, metabolic pathways, and large multi-component complexes. Protein abundance is regulated at multiple levels spanning transcription, translation, recycling, and degradation to maintain proper balance and optimal function. To better understand how protein abundances are maintained across varying genetic background...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b32d9e8-13fa-5a34-bcde-3a93e8599d7f
DOI: 10.1101/2020.09.18.296657

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of protein abundance in genetically diverse mouse populationsDOI 10.1101/2020.09.18.296657Read

Defining the consequences of genetic variation on a proteome-wide scale.Semantic proximity Read

Impact of genetic variation on synaptic protein levels in genetically diverse mice.Semantic proximity Read

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse modelSemantic proximity Read

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heartSemantic proximity Read

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic isletSemantic proximity Read

Genetic analysis of the mouse brain proteome.Semantic proximity Read

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneitySemantic proximity Read

Identification of Genetic Variants Regulating the Abundance of Clinically Relevant Plasma Proteins using the Diversity Outbred Mouse ModelSemantic proximity Read

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.Semantic proximity Read

Comparative analysis of proteome and transcriptome variation in mouse.Semantic proximity Read

Mouse protein coding diversity: What's left to discover?Semantic proximity Read

The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues.Semantic proximity Read