Article
The molecular basis of myeloid malignancies.
Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2014
Kitamura Toshio, Inoue Daichi, Okochi-Watanabe Naoko, Kato Naoko, Komeno Yukiko, Lu Yang, Enomoto Yutaka, Doki Noriko, Uchida Tomoyuki, Kagiyama Yuki, Togami Katsuhiro, Kawabata Kimihito C, Nagase Reina, Horikawa Sayuri, Hayashi Yasutaka, Saika Makoto, Fukuyama Tomofusa, Izawa Kumi, Oki Toshihiko, Nakahara Fumio, Kitaura Jiro
Abstract excerpt
Myeloid malignancies consist of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and myeloproliferative neoplasm (MPN). The latter two diseases have preleukemic features and frequently evolve to AML. As with solid tumors, multiple mutations are required for leukemogenesis. A decade ago, these gene alterations were subdivided into two categories: class I mutations stimulating cell growth or inhibiting...
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