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Article

Multistep pathogenesis of chronic myelomonocytic leukemia in patients.

European journal of haematology - 1 Jul 2022

Geissler Klaus, Jäger Eva, Barna Agnes, Gurbisz Michael, Marschon Renate, Graf Temeida, Nösslinger Thomas, Pfeilstöcker Michael, Machherndl-Spandl Sigrid, Stauder Reinhard, Zebisch Armin, Sill Heinz, Öhler Leopold, Kusec Rajko, Hoermann Gregor, Valent Peter

Abstract excerpt

BACKGROUND: A multistep pathogenesis of myeloid leukemia including mutations in epigenetic, spliceosome, and signaling genes has been recently demonstrated in a preclinical model but is poorly validated in patients. METHODS: Clinical, phenotypic, and biologic features were compared between three distinct molecularly defined CMML cohorts including TET2 monomutated patients (T, n = 10), TET2/SRSF2 bimutated...

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Identifiers

PMID: 35299281
DOI: 10.1111/ejh.13768
PMCID: PMC9310570

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