Article

LDER-GE estimates phenotypic variance component of gene-environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information

2023-11-23

Abstract excerpt

Gene-environment (GE) interactions are essential in understanding human complex traits. Identifying these interactions is necessary for deciphering the biological basis of such traits. In this study, we introduce a statistical method Linkage-Disequilibrium Eigenvalue Regression for Gene-Environment interactions (LDER-GE). LDER-GE improves the accuracy of estimating the phenotypic variance component explained by ge...

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Literature Corpus work: e06f28a3-542a-57b9-a4f5-e4f584186b98
DOI: 10.1101/2023.11.22.568329

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