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Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

3 Feb 2025

Abstract excerpt

Large-scale changes in the structure and cellular makeup of the distal lung are a hallmark of pulmonary fibrosis (PF), but the spatial contexts that contribute to disease pathogenesis have remained uncertain. Using image-based spatial transcriptomics, we analyzed the gene expression of 1.6 million cells from 35 unique lungs. Through complementary cell-based and innovative cell-agnostic analyses, we characterized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39901013
DOI: 10.1038/s41588-025-02080-x

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