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The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis

2025-07-08

Abstract excerpt

<h4>Background</h4> Pleuroparenchymal fibroelastosis (PPFE) is a progressive interstitial lung disease with higher prevalence in females, histologically characterized by intra-alveolar fibrosis with septal elastosis (AFE). Effective treatments are lacking, highlighting the need to dissect its pathogenesis at single-cell resolution. <h4>Methods</h4> We performed single-nucleus RNA sequencing (snRNAseq) on explant...

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Literature Corpus work
f272df1f-589e-590b-a017-ce7cb2157648
DOI
10.1101/2025.07.06.663336
Open publication

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The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosisDOI 10.1101/2025.07.06.663336
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