Article

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

2022-01-22

Abstract excerpt

<h4>SUMMARY</h4> It is currently accepted that activated cancer-associated fibroblasts (CAF) participate in T cell exclusion from tumor nests, but it remains unclear how they promote barrier phenotypes, and whether specific subsets are involved. Here, using single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors, we identify four main CAF populations, of which only two are assoc...

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Literature Corpus work: e05cdf2f-1b61-5d46-8864-9356f5ac891a
DOI: 10.1101/2022.01.20.476763

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