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Article

Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features.

Journal of the National Cancer Institute - 10 Jan 2023

Pellinen Teijo, Paavolainen Lassi, Martín-Bernabé Alfonso, Papatella Araujo Renata, Strell Carina, Mezheyeuski Artur, Backman Max, La Fleur Linnea, Brück Oscar, Sjölund Jonas, Holmberg Erik, Välimäki Katja, Brunnström Hans, Botling Johan, Moreno-Ruiz Pablo, Kallioniemi Olli, Micke Patrick, Östman Arne

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer anti- and protumorigenic functions. Prior in situ profiling studies of human CAFs have largely relied on scoring single markers, thus presenting a limited view of their molecular complexity. Our objective was to study the complex spatial tumor...

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Identifiers

PMID: 36083003
DOI: 10.1093/jnci/djac178

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