Article
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.
Cancer cell - 14 Nov 2022
Foster Deshka S, Januszyk Michael, Delitto Daniel, Yost Kathryn E, Griffin Michelle, Guo Jason, Guardino Nicholas, Delitto Andrea E, Chinta Malini, Burcham Austin R, Nguyen Alan T, Bauer-Rowe Khristian E, Titan Ashley L, Salhotra Ankit, Jones R Ellen, da Silva Oscar, Lindsay Hunter G, Berry Charlotte E, Chen Kellen, Henn Dominic, Mascharak Shamik, Talbott Heather E, Kim Alexia, Nosrati Fatemeh, Sivaraj Dharshan, Ransom R Chase, Matthews Michael, Khan Anum, Wagh Dhananjay, Coller John, Gurtner Geoffrey C, Wan Derrick C, Wapnir Irene L, Chang Howard Y, Norton Jeffrey A, Longaker Michael T
Abstract excerpt
Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment. CAFs were once thought to be a relatively uniform population of matrix-producing cells, but single-cell RNA sequencing has revealed diverse CAF phenotypes. Here, we further probed CAF heterogeneity with a comprehensive multiomics approach. Using paired, same-cell chromatin accessibility and transcriptome analysis, we provided...
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