Article

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

2024-06-09

Abstract excerpt

<h4>Summary</h4> Despite sustained clinical responses to immune-checkpoint blockade (ICB) therapies in non-small-cell lung cancer (NSCLC), the majority of patients derive no clinical benefits, and the cellular and molecular underpinnings of such resistance remain incompletely understood. To identify cell types that may influence immunotherapy responses, we first integrated newly generated and previously published...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19563abe-0de2-5478-aeec-a2cdc6d89189
DOI: 10.1101/2024.06.06.597777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancerDOI 10.1101/2024.06.06.597777Read

Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structuresSemantic proximity Read

Tumor microenvironment and drug resistance in lung adenocarcinoma: molecular mechanisms, prognostic implications, and therapeutic strategiesSemantic proximity Read

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity Read

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung AdenocarcinomaSemantic proximity Read

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma.Semantic proximity Read

Single-Cell RNA Sequencing Reveals Tumor Microenvironment Remodeling after Neoadjuvant Immunotherapy in Non-small Cell Lung CancerSemantic proximity Read

A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancerSemantic proximity Read

Phenotype molding of stromal cells in the lung tumor microenvironment.Semantic proximity Read

Distinct Spatial Programs of Response versus Resistance in Non-Small Cell Lung Cancer after Neoadjuvant ChemoimmunotherapySemantic proximity Read

An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung CancerSemantic proximity Read

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinomaSemantic proximity Read

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.Semantic proximity Read