Article

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cells

2024-06-04

Abstract excerpt

There are over fifty microsatellite expansion disorders, often neurodegenerative pathologies, due to large expansions of tandem repeat sequences. These microsatellites vary in motif composition, size and copy number in the genome. The ability of these repeats to form secondary structures in vitro is strongly suspected to trigger the expansion process and therefore, the pathology. However, there is no formal proof...

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Literature Corpus work: 403faf03-3ce8-5fed-bf31-8736ac476877
DOI: 10.1101/2024.06.04.597286

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