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Article

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats.

Cell reports - 20 Feb 2018

Mosbach Valentine, Poggi Lucie, Viterbo David, Charpentier Marine, Richard Guy-Franck

Abstract excerpt

Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington's disease. Because expansions trigger the disease, contracting repeat length could be a possible approach to gene therapy for these disorders. Here, we show that a TALEN-induced double-strand break was very efficient at contracting expanded CTG repeats in...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Saccharomyces cerevisiae

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Source

Identifiers

PMID: 29466740
DOI: 10.1016/j.celrep.2018.01.083

Genes

RAD50
RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats.PMID 29466740Read ↗

Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.Semantic proximity Read ↗

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangementsSemantic proximity Read ↗

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cellsSemantic proximity Read ↗

Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks.Semantic proximity Read ↗

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.Semantic proximity Read ↗

Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.Semantic proximity Read ↗

Massive contractions of Myotonic Dystrophy Type 2-associated CCTG tetranucleotide repeats occur via double strand break repair with distinct requirements for helicasesSemantic proximity Read ↗

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Semantic proximity Read ↗

CRISPR/Cas9-induced double-strand breaks in huntingtin locus lead to CAG repeat contraction through the extensive DNA end resection and homology-mediated repairSemantic proximity Read ↗

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.Semantic proximity Read ↗

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cellsSemantic proximity Read ↗

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Semantic proximity Read ↗

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