Article

CRISPR/Cas9-induced double-strand breaks in huntingtin locus lead to CAG repeat contraction through the extensive DNA end resection and homology-mediated repair

2023-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Expansion of the CAG/CTG repeats in functionally unrelated genes is a causative factor in many inherited neurodegenerative disorders, including Huntington’s disease (HD), spinocerebellar ataxias (SCAs) and myotonic dystrophy type 1 (DM1). Despite many years of research, the mechanism responsible for repeat instability is unknown, and recent findings indicate the key role of DNA repair in this pr...

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Literature Corpus work: b32bd00b-5152-5727-953b-0ce9f3771b13
DOI: 10.1101/2023.11.24.568568

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