Back to search

Article

Natural genetic variation screen in <i>Drosophila</i> identifies Wnt signaling, mitochondrial metabolism, and redox homeostasis genes as modifiers of apoptosis

2019-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Apoptosis is the primary cause of degeneration in a number of neuronal, muscular, and metabolic disorders. These diseases are subject to a great deal of phenotypic heterogeneity in patient populations, primarily due to differences in genetic variation between individuals. This creates a barrier to effective diagnosis and treatment. Understanding how genetic variation influences apoptosis could l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e048f745-73d9-518e-9e26-59aae929af69
DOI
10.1101/670075
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Natural genetic variation screen in <i>Drosophila</i> identifies Wnt signaling, mitochondrial metabolism, and redox homeostasis genes as modifiers of apoptosisDOI 10.1101/670075
Behavioral screening defines three molecular Parkinsonism subgroups in <i>Drosophila</i>Semantic proximity
Probing Mechanisms That Underlie Human Neurodegenerative Diseases in <i>Drosophila</i>Semantic proximity
Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicitySemantic proximity
An <i>in vivo</i> platform to identify pathogenic lociSemantic proximity
A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of <i>Sirt1</i>Semantic proximity
Insights into Dentatorubral-Pallidoluysian Atrophy from a new <i>Drosophila</i> model of diseaseSemantic proximity
Genetic basis of maneb-induced dopaminergic neurodegeneration in <i>Drosophila</i>Semantic proximity
Behavioral screening defines the molecular Parkinsonism-related subgroups in Drosophila.Semantic proximity
The <i>Drosophila</i> metallopeptidase <i>superdeath</i> decouples apoptosis from the activation of the ER stress responseSemantic proximity
<i>Drosophila</i> models of pathogenic copy-number variant genes show global and non-neuronal defects during developmentSemantic proximity
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.Semantic proximity
Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in <i>Drosophila</i>Semantic proximity
Select a neighboring publication to make it the new centre.