Article

Genetic basis of maneb-induced dopaminergic neurodegeneration in <i>Drosophila</i>

2025-05-12

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is a complex neurodegenerative disease driven by combined genetic and environmental factors. Human studies support increased PD risk following exposure to the pesticide maneb yet animal studies generally report subtle or no dopaminergic phenotypes unless maneb is combined with additional pesticides. Consequently, it is unclear whether exposure to maneb alone promotes dop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb638afe-55c0-5f9e-85ed-8ec5548d77b7
DOI: 10.1101/2025.05.07.652747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic basis of maneb-induced dopaminergic neurodegeneration in <i>Drosophila</i>DOI 10.1101/2025.05.07.652747Read

Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in <i>Drosophila</i>Semantic proximity Read

Genetic Modifiers of Pathogenic LRRK2 G2019S Neurodegeneration in <i>Drosophila</i>Semantic proximity Read

Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease.Semantic proximity Read

AxGxE: Using Flies to Interrogate the Complex Etiology of Neurodegenerative Disease.Semantic proximity Read

Micro-/nano-plastics accentuate Parkinson’s Disease-relevant phenotypes in a <i>Drosophila</i> modelSemantic proximity Read

Understanding role of pesticides in development of Parkinson's disease: Insights from Drosophila and rodent modelsSemantic proximity Read

Interaction of genetic and environmental factors in a Drosophila parkinsonism model.Semantic proximity Read

Comparative Proteomic Analysis of Environmental and Genetic Models of Parkinson’s Disease Highlights the Role of Purine MetabolismSemantic proximity Read

Exploring the versatility of Drosophila melanogaster as a model organism in biomedical research: a comprehensive reviewSemantic proximity Read

Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicitySemantic proximity Read

Drosophila Models of Human DiseaseSemantic proximity Read

Probing Mechanisms That Underlie Human Neurodegenerative Diseases in <i>Drosophila</i>Semantic proximity Read